Key result
Monomeric myosin V (MV 1IQ) binds actin with a Kd of 4 microM, which is 10-20-fold tighter than nonprocessive class II myosins.
Population
Monomeric myosin V containing a single IQ domain (MV 1IQ) and actin filaments
Comparison
Non-hydrolyzable nucleotide analogues and… vs Conventional nonprocessive class II myosins
Design
Preclinical
Authors
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May reflect specialized weak-state kinetics in myosin V; leaves open extension to cardiac myosins in vivo.
Myosin V exhibits significantly tighter actin binding in weak binding states compared to conventional class II myosins, suggesting unique conformational changes in the nucleotide binding pocket upon actin binding.
Yengo et al. (2002) studied this question. Monomeric myosin V (MV 1IQ) vs. Nonprocessive class II myosins was evaluated on Actin binding affinity (Kd). Monomeric myosin V (MV 1IQ) binds actin with a Kd of 4 microM, which is 10-20-fold tighter than nonprocessive class II myosins.
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