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January 23, 2013Diabetes CareOpen Access

Elevated inflammatory markers were associated with progression of coronary artery calcification in adults with and without type 1 diabetes (OR 1.38; 95% CI 1.08-1.77).

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Why the study?

Are inflammatory markers associated with the progression of coronary artery calcification in adults with and without type 1 diabetes?

Population

462 adults with and without type 1 diabetes

Comparison

Elevated inflammatory markers vs Lower levels of inflammatory markers

Design

Case-control

Follow-up

~2.5 years

Key result

Elevated inflammatory markers were associated with progression of coronary artery calcification in adults with and without type 1 diabetes (OR 1.38; 95% CI 1.08-1.77).

Authors

AAAmy C. AlmanGKGregory L. KinneyRTRussell P. Tracy

Discussion

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Member takes

Overview

May inform risk stratification; leaves open whether targeting inflammation alters CAC progression in type 1 diabetes.

Study Design

Type

Case-Control (n=462)

Structured PICO

Are inflammatory markers associated with the progression of coronary artery calcification in adults with and without type 1 diabetes?

P
Population
462 adults with and without type 1 diabetes, followed for ~2.5 years to assess the association between inflammatory markers and progression of coronary artery calcification.
E
Exposure
Elevated inflammatory markers (assessed via principal components analysis and a composite score)
C
Comparator
Lower levels of inflammatory markers
O
Outcome
Significant progression of coronary artery calcification (CAC) over ~2.5 yearssurrogate

Main Result

Odds Ratio: 1.38 (95% CI 1.08–1.77)

Elevated inflammatory markers are associated with the progression of subclinical atherosclerosis, measured by coronary artery calcification, in adults with and without type 1 diabetes.

Cite This Study

Alman et al. (2013) conducted a case-control in Type 1 diabetes and coronary artery calcification (n=462). Elevated inflammatory markers vs. Lower levels of inflammatory markers was evaluated on Progression of coronary artery calcification (OR 1.38, 95% CI 1.08-1.77). Elevated inflammatory markers were associated with progression of coronary artery calcification in adults with and without type 1 diabetes (OR 1.38; 95% CI 1.08-1.77).

synapsesocial.com/papers/6a20e50434bef10fdaeb1c6ehttps://doi.org/10.2337/dc12-1874
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Progression of Coronary Artery Calcification in Type 1 Diabetes2003 · 140 citations
  2. 2Burden and progression of arterial calcification in type 1 diabetes predicts future cardiovascular disease2025 · 1 citations
  3. 3Coronary artery calcification is associated with insulin resistance index in patients with type 1 diabetes2010 · 20 citations
  4. 4Coronary artery calcification in Type 2 diabetes mellitus: biochemical and inflammatory insights from the Pakistani Population- a case-control study2026
  5. 5Ideal Cardiovascular Health and the Prevalence and Progression of Coronary Artery Calcification in Adults With and Without Type 1 Diabetes2013 · 54 citations