Association between the LIPG polymorphisms and serum lipid levels in the Maonan and Han populations

Figures

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  Figure 1. The PCR products of the samples and the genotypes of the LIPG SNPs. Lane M is the 100‐bp marker ladder; (A to C) lanes 1–6 are the PCR products: A, rs2156552 SNP (206 bp); B, rs4939883 SNP (427 bp); C, rs7241918 SNP (512 bp); D, genotyping of the rs2156552 SNP: lanes 1 and 2, TT genotype (206 bp); lanes 3 and 4, AA genotype (147 and 59 bp); and lanes 5 and 6, AT genotype (206, 147 and 59 bp); E, genotyping of the rs4939883 SNP: lanes 1, 3 and 6, CC genotype (343 and 84 bp); lanes 2, TT genotype (427 bp); and lanes 4 and 5, CT genotype (427, 343 and 84 bp); F, genotyping of the rs7241918 SNP: lanes 1 and 2, GT genotype (512‐, 416‐ and 96‐bp); lanes 3 and 4, GG genotype (416 and 96 bp); and lanes 5 and 6, TT genotype (512 bp)

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  Figure 2. A part of the nucleotide sequences of the LIPG SNPs. A, rs2156552 SNP; B, rs4939883 SNP; C, rs7241918 SNP

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  Figure 3. The genotypic and allelic frequencies of the LIPG SNPs in the Maonan and Han populations. Allele A: rs2156552A, rs4939883C, or rs7241918T; allele B: rs2156552T, rs4939883T, or rs7241918G; genotype AA: rs2156552AA, rs4939883CC, or rs7241918TT; genotype AB: rs2156552AT, rs4939883CT, or rs7241918GT; genotype BB: rs2156552TT, rs4939883TT, or rs7241918GG. a p < 0.05; b p < 0.01; p HWE > 0.05 for all

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  Figure 4. The genotypic and allelic frequencies of the LIPG SNPs between males (M) and famales (F) in the Maonan and Han populations. Allele A: rs2156552A, rs4939883C, or rs7241918T; allele B: rs2156552T, rs4939883T, or rs7241918G; genotype AA: rs2156552AA, rs4939883CC, or rs7241918TT; genotype AB: rs2156552AT, rs4939883CT, or rs7241918GT; genotype BB: rs2156552TT, rs4939883TT, or rs7241918GG. a p < 0.05; b p < 0.01; p HWE > 0.05 for all

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  Figure 5. The LIPG genotypes and serum lipid levels in the Han and Maonan populations. TC, total cholesterol; TG, triglyceride; HDL‐C, high‐density lipoprotein cholesterol; LDL‐C, low‐density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/ApoB, the ratio of apolipoprotein A1 to apolipoprotein B. The value of TG is presented as the median (interquartile range). The difference between the genotypes was determined by the Kruskal–Wallis test. The p‐value was calculated by ANCOVA, using general linear models, and adjusted for age, sex, body mass index, smoking status, alcohol use, glucose and hypertension; p < 0.0167 was considered statistically significant after adjusting by the Bonferroni correction). a p < 0.0167; b p < 0.001

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  Figure 6. The LIPG genotypes and serum lipid levels in males and females of the Han and Maonan populations. TC, total cholesterol; TG, triglyceride; HDL‐C, high‐density lipoprotein cholesterol; LDL‐C, low‐density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/ApoB, the ratio of apolipoprotein A1 to apolipoprotein B. The value of TG is presented as the median (interquartile range). The difference between the genotypes was determined by the Kruskal–Wallis test. The p‐value was calculated by ANCOVA, using general linear models, and adjusted for age, sex, body mass index, smoking status, alcohol use, glucose and hypertension; p < 0.0167 was considered statistically significant after adjusting by the Bonferroni correction). a p < 0.0167; b p < 0.001