Association between the MVK and MMAB polymorphisms and serum lipid levels

Figures

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  Figure 1. Frequencies of the genotype (A) and allele (B) in the Han and Maonan populations (A) AA, rs3759387AA, rs877710CC, rs7134594CC, and rs9593AA genotypes; AB, rs3759387AC, rs877710CG, rs7134594CT, and rs9593AT genotypes; BB, rs3759387CC, rs877710GG, rs7134594TT, and rs9593TT genotypes. (B) A, rs3759387A, rs877710C, rs7134594C, and rs9593A alleles; B, rs3759387C, rs877710G, rs7134594T, and rs9593T alleles; aP < 0.05; bP < 0.01; cP < 0.001; PHWE > 0.05 for all.

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  Figure 2. Comparison of the genotypes and serum lipid levels between the Han and Maonan populations TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/ApoB, the ratio of apolipoprotein A1 to apolipoprotein B. The value of triglyceride was presented as median (interquartile range), the difference among the genotypes was determined by the Kruskal-Wallis test. P < 0.0125 (corresponding to P < 0.05 after adjusting for 4 independent tests by the Bonferroni correction) was considered statistically significant. The minor allele carriers had higher serum HDL-C and/or ApoA1 levels than the minor allele non-carriers. aP < 0.0125; bP < 0.001.

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  Figure 3. Lipid profiles according to the haplotypes of the two ethnic groups P < 0.0125 (corresponding to P < 0.05 after adjusting for 4 independent tests by the Bonferroni correction) was considered statistically significant. All of the detected haplotype carriers had higher serum HDL-C and/or ApoA1 levels than the haplotype non-carriers except for rs3759387C-rs877710G-rs7134594C-rs9593T carriers. aP < 0.0125; bP < 0.001.

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  Figure 4. The stratified risk factors and MVK/MMAB haplotypes associated with dyslipidemia in the Han and Maonan populations Stratified analysis showed an increased risk of dyslipidemia in female, high BMI, smoking, diabetes or hypertension subgroups and haplotype carriers, but not in drinking subgroup. aP < 0.05;bP < 0.01 and cP < 0.001.

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  Figure 5. Correlation between environmental exposures and serum lipid variables, as well as the candidate loci TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/ApoB, the ratio of apolipoprotein A1 to apolipoprotein B; BMI, body mass index.