Key result
A 1-SD increase in ANGPTL3 was associated with a 1.14 μg/mL increase in apoA-I in non-diabetic females, whereas ANGPTL3 levels were significantly reduced in female patients with type 2 diabetes.
Why the study?
Does the relationship between ANGPTL3 and HDL components/function differ between non-diabetic subjects and type-2 diabetic patients?
Population
598 Han Chinese adults, 50% female, mean age ~53-56 years, free of liver and kidney disorders. Also includes…
Design
Cross-sectional
Authors
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ANGPTL3-apoA-I association in non-diabetic females and lower levels in T2D may reflect diabetes-specific effects; hypothesis-generating, should not yet change practice.
Cross-Sectional (n=598)
No
Does the relationship between ANGPTL3 and HDL components/function differ between non-diabetic subjects and type-2 diabetic patients?
Mean Difference: 1.14 (95% CI 0.88–1.4)
p-value: p=<0.0001
Zhao et al. (2016) conducted a cross-sectional in Type 2 Diabetes Mellitus (n=598). ANGPTL3 vs. Lower ANGPTL3 levels was evaluated on Change in apoA-I per 1-SD increase in ANGPTL3 in non-diabetic females (MD 1.14 μg/mL, 95% CI 0.88-1.40, p=<0.0001). A 1-SD increase in ANGPTL3 was associated with a 1.14 μg/mL increase in apoA-I in non-diabetic females, whereas ANGPTL3 levels were significantly reduced in female patients with type 2 diabetes.
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