June 24, 2017Journal of the American Heart AssociationOpen Access

Angiopoietin‐Like Protein 4 Is a High‐Density Lipoprotein (HDL) Component for HDL Metabolism and Function in Nondiabetic Participants and Type‐2 Diabetic Patients

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Population

Nondiabetic participants and type 2 diabetes mellitus patients, along with ANGPTL4+/+ and ANGPTL4-/- mice.

Design

Cross-sectional

Authors

LYLongyan YangCapital Medical University CYCai‐Guo YuBeijing Luhe Hospital Affiliated to Capital Medical University XWXuhong WangHangzhou Women’s Hospital

Discussion

Member takes

Implication

Suggests a mechanism for HDL dysfunction in T2DM despite elevated ANGPTL.

Structured PICO

Population

Nondiabetic participants (n=201, 68.7% females) and type 2 diabetes mellitus (T2DM) patients (n=185, 66.5% females), along with ANGPTL4+/+ and ANGPTL4-/- mice.

Comparator

Nondiabetic controls (for human cohort); ANGPTL4+/+ mice (for animal cohort)

Outcome

ANGPTL4 levels in circulation and HDLs, cholesterol efflux, and endothelial lipase (EL) hydrolysissurrogate

ANGPTL4 in HDLs protects against hydrolysis, but in T2DM, despite elevated levels, its inhibitory effect on endothelial lipase is compromised, leading to HDL dysfunction.

Cite This Study

Yang et al. (2017) studied this question.

synapsesocial.com/papers/6a7d1775ec6dad7f5aaa096a https://doi.org/10.1161/jaha.117.005973

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Angiopoietin‐Like Protein 4 Is a High‐Density Lipoprotein (HDL) Component for HDL Metabolism and Function in Nondiabetic Participants and Type‐2 Diabetic Patients

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiopoietin‐Like Protein 4 Is a High‐Density Lipoprotein (HDL) Component for HDL Metabolism and Function in Nondiabetic Participants and Type‐2 Diabetic Patients

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider