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This research aims to clarify the renal responses to the renin-angiotensin system and the implications of its antagonism.

Renal responses to antagonism of the renin-angiotensin system

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This research aims to clarify the renal responses to the renin-angiotensin system and the implications of its antagonism.
Reviewed recent developments in the intrarenal formation of the renin-angiotensin system.
Discussed interactions between angiotensin II and nitric oxide in renal function.
Evaluated the differences between angiotensin-converting enzyme inhibitors and AT1 receptor antagonists.
Angiotensin II influences renal actions through AT1 receptors, with distinct mechanisms than ACE inhibitors.
Recent polymorphisms in the ACE gene show significant variability in angiotensin-converting enzyme levels.
Emerging concepts suggest a more complex role of the intrarenal renin-angiotensin system than previously understood.

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No immediate change to RAS inhibitor prescribing; leaves open whether intrarenal distinctions affect outcomes in trials.

Braam et al. (1996) studied this question.

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