Population
two-kidney, one-clip (2K1C) Goldblatt hypertensive rat model
Design
Review
Authors
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Offers mechanistic rationale for ARB renal effects; hypothesis-generating and should not yet change practice.
AT1 receptor blockers improve renal hemodynamics and increase sodium excretion, providing a mechanistic basis for their long-term efficacy in controlling hypertension.
L NAVAR (2000) studied this question.
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