Key result
Increased premature activation frequency and QTI dynamics instability precede ventricular tachycardia onset in patients with acute myocardial infarction.
Why the study?
Does a novel methodology for detecting QT interval dynamics instability identify changes preceding ventricular tachycardia onset in patients with acute myocardial infarction?
Population
24 patients with acute myocardial infarction, plus an MRI-based human ventricular model for pseudo-ECG…
Comparison
Assessment of QT interval dynamics instability… vs Assessment in a 10-minute control ECG recording…
Design
Cohort
Authors
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May support ECG monitoring of QT instability to anticipate VT in AMI; leaves open prospective validation and outcome impact.
Observational (n=24)
Does a novel methodology for detecting QT interval dynamics instability identify changes preceding ventricular tachycardia onset in patients with acute myocardial infarction?
Increased premature activation frequency and QT interval dynamics instability can be detected from clinical ECGs and precede ventricular tachycardia onset in patients with acute myocardial infarction.
Chen et al. (2011) conducted an observational in acute myocardial infarction (n=24). Onset epoch (right before VT onset) vs. Control epoch (at least 1 hour before VT onset) was evaluated on Frequency of premature activations and number of minECGs with unstable QTI dynamics. Increased premature activation frequency and QTI dynamics instability precede ventricular tachycardia onset in patients with acute myocardial infarction.
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