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April 1, 1973Proceedings of the National Academy of SciencesOpen Access

Oligoclonal IgG Antibody Response in the Central Nervous System to Different Measles Virus Antigens in Subacute Sclerosing Panencephalitis

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Population

2 patients with subacute sclerosing panencephalitis

Design

Case_series

Authors

BVBodvar VandvikOslo University HospitalENErling NorrbyUppsala University

Discussion

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Implication

May support SSPE diagnostic specificity; leaves open validation in larger cohorts before broader use.

Structured PICO

P
Population
2 patients with subacute sclerosing panencephalitis
I
Intervention
Agarose electrophoresis and crossed immunoelectrophoresis of cerebrospinal fluid
O
Outcome
Identification and characterization of oligoclonal IgG bands and their measles virus-specific antibody activitiessurrogate

Oligoclonal IgG bands in the cerebrospinal fluid of patients with subacute sclerosing panencephalitis represent homogeneous, and sometimes monoclonal, measles virus-specific antibodies directed against different viral antigens.

Cite This Study

Vandvik et al. (1973) studied this question.

synapsesocial.com/papers/6a20ec306dd54ee3d3eb2a2chttps://doi.org/10.1073/pnas.70.4.1060
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Appearance and Persistence of Antibodies Against Different Virus Components After Regular Measles Infections1972 · 141 citations