Why the study?
Can a radioimmunoassay detect and distinguish IgG and IgM measles antibodies in the CSF and serum of patients with multiple sclerosis and other neurologic diseases?
Can a radioimmunoassay detect and distinguish IgG and IgM measles antibodies in the CSF and serum of patients with multiple sclerosis and other neurologic diseases?
A novel radioimmunoassay can detect and differentiate IgG and IgM antibodies against measles viral structural components in the CSF and serum of patients with neurologic diseases.
Detects measles antibodies in MS CSF; leaves open etiologic significance and needs prospective validation before any diagnostic use.
Evidence that different structural components of the measles virus may act as antigens has been provided by the serologic methods of hemagglutination inhibition hemolysin inhibition, and nucleocapsid complement fixation. Using radioiodinated measles viral antigens, and immune precipitation assay has been designed that is capable of discriminating among various reactivities to measles viral structural components in serum or cerebrospinal fluid (CSF) and of distinguishing whether IgG and IgM antibody is involved. This technique has been applied to the study of measles antibodies in CSF and sera of patients with multiple sclerosis (MS) and other neurologic diseases. From data presented here, it was found that both groups of patients have individual reactivity to measles proteins, present in CSF and serum, whereas three normal CSF samples were found not to have such antibodies. It appears that oligoclonal immunoglobulins in CSF of MS patients may be detected by this method, and one patient with MS was found to have CSF IgM anti-measles antibodies.
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Cunningham‐Rundles et al. (1975) studied this question.
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