October 1, 1970Neurology

Measles antibodies in patients with multiple sclerosis and with other neurological and nonneurological diseases

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Why the study?

Are measles antibody titers higher in patients with multiple sclerosis compared to control subjects?

Population

305 patients, including 133 diagnosed with multiple sclerosis and 172 control subjects.

Design

Case-control

Authors

JAJohn M. AdamsThe University of Texas Health Science Center at San Antonio MBMilo B. BrooksUniversity of California, Los Angeles EFEdison D. FisherUniversity of California, Los Angeles

Discussion

Member takes

Implication

Higher titers should not guide MS care or testing; leaves open viral persistence hypothesis for prospective validation.

Structured PICO

Are measles antibody titers higher in patients with multiple sclerosis compared to control subjects?

Population

305 patients, including 133 diagnosed with multiple sclerosis (MS) and 172 control subjects (neurological patients without MS and patients with nonneurological illnesses).

Comparator

Control subjects (neurological patients without MS and patients with nonneurological illnesses)

Outcome

Measles antibody titers detected by hemagglutination-inhibition testsurrogate

Patients with multiple sclerosis have significantly higher measles antibody titers than controls, suggesting potential viral persistence.

Cite This Study

Adams et al. (1970) studied this question.

synapsesocial.com/papers/6a8aedafeada60f85de3aa91 https://doi.org/10.1212/wnl.20.10.1039

View Full Paper

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Measles antibodies in patients with multiple sclerosis and with other neurological and nonneurological diseases

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Measles antibodies in patients with multiple sclerosis and with other neurological and nonneurological diseases

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider