Key result
Patients with atypical measles showed a pronounced antibody response to M antigen, whereas patients with SSPE and chronic active hepatitis had high titers to NP but low or undetectable antibodies to M antigen.
Population
47 serum samples from patients with early regular measles convalescent, late regular measles convalescent…
Design
Cross-sectional
Authors
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May support serological differentiation of atypical measles from SSPE; leaves open prospective validation before diagnostic use.
Observational (n=47)
The study demonstrates that the antibody response to the measles virus matrix (M) antigen varies significantly across different disease conditions, being notably weak in SSPE and chronic active hepatitis but pronounced in atypical measles.
Norrby et al. (1981) conducted an observational in Measles, Subacute Sclerosing Panencephalitis, Multiple Sclerosis, Chronic Active Hepatitis (n=47). Different disease conditions (SSPE, MS, chronic active hepatitis, atypical measles) vs. Early and late measles convalescent sera was evaluated on Occurrence and titers of antibodies to nucleoprotein (NP) and matrix (M) antigens of measles virus. Patients with atypical measles showed a pronounced antibody response to M antigen, whereas patients with SSPE and chronic active hepatitis had high titers to NP but low or undetectable antibodies to M antigen.
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