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September 1, 1972Infection and ImmunityOpen Access

Appearance and Persistence of Antibodies Against Different Virus Components After Regular Measles Infections

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Population

Sera from patients with acute, early and late regular measles infections, gamma globulin, and sera from two…

Design

Other

Follow-up

up to 4 to 20 years postinfection

Authors

ENErling NorrbyUppsala UniversityYGYlva GollmarUniversity of Turku

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Implication

Nucleocapsid-focused serology may aid measles immunity assessment; leaves open extension to vaccines or other paramyxoviruses.

Structured PICO

P
Population
Sera from patients with acute, early (11 to 40 days after rash) and late (4 to 20 years postinfection) regular measles infections, gamma globulin, and sera from two patients with multiple sclerosis.
O
Outcome
Measles virus-specific antibody activities (neutralization, hemolysis-inhibiting, hemagglutinating-inhibiting, complement-fixation, and immunodiffusion)surrogate

Antibodies against nucleocapsid structures are the dominant persisting antibodies after regular measles infections.

Cite This Study

Norrby et al. (1972) studied this question.

synapsesocial.com/papers/6a8aed7cf8241cb45bfb40d6https://doi.org/10.1128/iai.6.3.240-247.1972
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hemagglutination by Measles Virus. 4. A Simple Procedure for Production of High Potency Antigen for Hemagglutination-Inhibition (HI) Tests1962 · 216 citations
  2. 2Heterogeneity in the Properties of 7 S and 19 S Rabbit-Neutralizing Antibodies to Herpes Simplex Virus1968 · 100 citations
  3. 3Patterns of Measles Antibodies in Residents of Tahiti and Their Stability in the Absence of Re-Exposure1962 · 76 citations