Key result
During an 8 to 9 year follow-up, 11 of 27 children (40.7%) immunized with 4 doses of inactivated measles vaccine showed clinical or serological signs of wild measles infection.
Why the study?
What is the long-term clinical and serological outcome of children immunized with formalin-inactivated measles vaccine or purified hemagglutinin?
Population
27 children immunized with 4 doses of formalin-inactivated vaccine and/or purified hemagglutinin prepared…
Design
Cohort
Follow-up
8-9 years post-booster
Authors
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May indicate inadequate long-term protection from inactivated measles vaccine; leaves open optimal antigen requirements for durable immunity.
Cohort (n=27)
What is the long-term clinical and serological outcome of children immunized with formalin-inactivated measles vaccine or purified hemagglutinin?
HI antibodies of a certain minimal concentration can block the replication of vaccine virus even in the absence of non-HI HLI antibodies, suggesting future vaccines should include both hemagglutinin and hemolysin.
Norrby et al. (1976) conducted a cohort in Measles vaccination (n=27). Formalin-inactivated vaccine and/or purified hemagglutinin was evaluated on Clinical and/or serological signs of infections with wild measles virus. During an 8 to 9 year follow-up, 11 of 27 children (40.7%) immunized with 4 doses of inactivated measles vaccine showed clinical or serological signs of wild measles infection.
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