Why the study?
Does chlorothiazide lower blood pressure through plasma and extracellular fluid volume depletion?
Design
Other
Follow-up
1 year
Authors
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Initial chlorothiazide BP reduction tracks volume loss; long-term efficacy implicates non-volume mechanisms, leaving precise pathways unresolved.
Does chlorothiazide lower blood pressure through plasma and extracellular fluid volume depletion?
The early antihypertensive effect of chlorothiazide is driven by volume depletion, but its long-term efficacy at 1 year is mediated by other mechanisms as extracellular fluid reaccumulates.
Wilson et al. (1959) studied this question.
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