Key result
Long-term chlorothiazide therapy moderately reduces blood pressure in 66% of hypertensive patients by decreasing total peripheral resistance rather than cardiac output.
Why the study?
Does long-term therapy with chlorothiazide reduce blood pressure and alter hemodynamics in patients with hypertension?
Does long-term therapy with chlorothiazide reduce blood pressure and alter hemodynamics in patients with hypertension?
Long-term chlorothiazide therapy lowers blood pressure in hypertensive patients primarily by reducing total peripheral resistance.
May inform thiazide selection in hypertension; leaves open randomized confirmation of long-term effects.
Long-term treatment of hypertension with chlorothiazide alone produces mioderate reduction in blood pressure in 66 per cent of patients with hypertension. This fall in pressure is due to a reduction in total peripheral resistance rather than a fall in cardiac output.
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Conway et al. (1960) studied this question. Long-term chlorothiazide therapy moderately reduces blood pressure in 66% of hypertensive patients by decreasing total peripheral resistance rather than cardiac output.
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