Key result
Long-term chlorothiazide therapy moderately reduces blood pressure in 66% of hypertensive patients by decreasing total peripheral resistance rather than cardiac output.
Why the study?
Does long-term therapy with chlorothiazide reduce blood pressure and alter hemodynamics in patients with hypertension?
Does long-term therapy with chlorothiazide reduce blood pressure and alter hemodynamics in patients with hypertension?
Long-term chlorothiazide therapy lowers blood pressure in hypertensive patients primarily by reducing total peripheral resistance.
Answers are grounded in this paper and cite their sources.
May inform thiazide selection in hypertension; leaves open randomized confirmation of long-term effects.
Long-term treatment of hypertension with chlorothiazide alone produces mioderate reduction in blood pressure in 66 per cent of patients with hypertension. This fall in pressure is due to a reduction in total peripheral resistance rather than a fall in cardiac output.
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Conway et al. (1960) studied this question. Long-term chlorothiazide therapy moderately reduces blood pressure in 66% of hypertensive patients by decreasing total peripheral resistance rather than cardiac output.
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