Hemodynamic Alterations in Hypertensive Patients Due to Chlorothiazide

ONLY two studies have been published that detail the changes in cardiac output after chlorothiazide.1 , 2 Other reports3 , 4 have alluded to the changes in cardiac output without tabulating any data. In the studies in which results were reported in detail, cardiac output was performed by the dye-dilution technic. Aleksandrow and his co-workers1 reported variable results in 7 hypertensive patients whereas Dustan and her associates2 demonstrated a consistent decrease. This communication reports on a series of hypertensive patients in whom cardiac output was measured before and after administration of chlorothiazide. In the majority of patients the direct Fick method was used, the . . .