Why the study?
What is the mechanism by which chlorothiazide enhances the effectiveness of antihypertensive ganglioplegic drugs?
Population
Subjects with chronic arterial hypertension
Design
Other
Authors
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May explain thiazide synergy with ganglioplegics via volume depletion; leaves open relevance to modern regimens.
What is the mechanism by which chlorothiazide enhances the effectiveness of antihypertensive ganglioplegic drugs?
Chlorothiazide enhances the efficacy of ganglioplegic antihypertensives through volume depletion and subsequent stimulation of vasomotor tone.
Dustan et al. (1959) studied this question.
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