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September 1, 1970CirculationOpen Access

Changes in Plasma and Extracellular Fluid Volumes in Patients with Essential Hypertension During Long-Term Treatment with Hydrochlorothiazide

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Why the study?

Does hydrochlorothiazide reduce plasma and extracellular fluid volumes in untreated patients with essential hypertension?

Population

13 untreated patients with essential hypertension

Comparison

Hydrochlorothiazide 50 to 100 mg daily for up to… vs Baseline (three control values before treatment)

Design

Cohort

Follow-up

up to 6 months

Authors

ALArne LethUniversity of Copenhagen

Discussion

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Implication

Supports sustained volume reduction with hydrochlorothiazide in hypertension; extends mechanistic data but leaves open clinical impact in randomized trials.

Structured PICO

Does hydrochlorothiazide reduce plasma and extracellular fluid volumes in untreated patients with essential hypertension?

P
Population
13 untreated patients with essential hypertension
I
Intervention
Hydrochlorothiazide 50 to 100 mg daily for up to 6 months
C
Comparator
Baseline (three control values before treatment)
O
Outcome
Plasma volume (T-1824) and extracellular fluid volume (82 Br - distribution space)surrogate

Long-term treatment with hydrochlorothiazide produces a sustained volume-depleting effect in patients with essential hypertension.

Cite This Study

Arne Leth (1970) studied this question.

synapsesocial.com/papers/6a7243eb2163a0a01bc605dahttps://doi.org/10.1161/01.cir.42.3.479
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Body Fluid Volumes and the Response of Renin and Aldosterone to Short‐ and Long‐Term Thiazide Therapy of Essential Hypertension1980 · 27 citations
  2. 2Hemodynamic changes during long-term thiazide treatment of essential hypertension in responders and nonresponders1980 · 118 citations
  3. 3Long-Term Thiazide Therapy in Essential Hypertension1970 · 216 citations
  4. 4Long-Term versus Short-Term Effects of Hydrochlorothiazide on Renal Haemodynamics in Essential Hypertension1979 · 33 citations
  5. 5HEMODYNAMIC CHANGES IN LONG‐TERM DIURETIC THERAPY OF ESSENTIAL HYPERTENSION1970 · 124 citations