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January 12, 1980Acta Medica Scandinavica

Body Fluid Volumes and the Response of Renin and Aldosterone to Short‐ and Long‐Term Thiazide Therapy of Essential Hypertension

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Why the study?

Does hydrochlorothiazide alter body fluid volumes, renin, and aldosterone in male patients with uncomplicated essential hypertension?

Population

9 male patients with uncomplicated essential hypertension

Comparison

Hydrochlorothiazide 50 mg oral twice daily for 1… vs Baseline (before treatment)

Design

Cohort

Follow-up

4 months

Authors

PBP. van BrummelenLeiden UniversityMSMaarten A.D.H. SchalekampGeneral / Preventive / Lipids

Discussion

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Implication

Chronic HCTZ sustains ECF reduction with elevated renin-aldosterone; hypothesis-generating for volume effects and should not yet change practice.

Structured PICO

Does hydrochlorothiazide alter body fluid volumes, renin, and aldosterone in male patients with uncomplicated essential hypertension?

P
Population
9 male patients with uncomplicated essential hypertension
I
Intervention
Hydrochlorothiazide 50 mg oral twice daily for 1 week and 4 months
C
Comparator
Baseline (before treatment)
O
Outcome
Changes in plasma volume (PV), extracellular fluid volume (ECV), serum electrolytes, renin, and aldosteronesurrogate

Long-term hydrochlorothiazide therapy causes a permanent decrease in extracellular fluid volume and sustained elevation of renin and aldosterone, with the renin response driven by fluid volume changes initially and serum sodium chronically.

Cite This Study

Brummelen et al. (1980) studied this question.

synapsesocial.com/papers/6a729d5235aa2c282ce35812https://doi.org/10.1111/j.0954-6820.1980.tb09718.x

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relationship Between Plasma and Extracellular Fluid Volume Depletion and the Antihypertensive Effect of Chlorothiazide1959 · 184 citations
  2. 2Renin–Angiotensin System in Mild Essential Hypertension. the Functional Significance of Angiotensin II in Untreated and Thiazide-Treated Hypertensive Patients1978 · 21 citations
  3. 3A Mechanism of Chlorothiazide-Enhanced Effectiveness of Antihypertensive Ganglioplegic Drugs1959 · 134 citations
  4. 4Long-Term Thiazide Therapy in Essential Hypertension1970 · 216 citations
  5. 5β-Adrenergic Blockade in Diuretic-Treated Patients with Essential Hypertension1975 · 115 citations