Key result
Elevated plasma renin activity linked to ~1.1 mmol/L less glucose reduction during hydrochlorothiazide therapy.
Why the study?
The relationship between changes in RAAS activity and plasma glucose after long-term hydrochlorothiazide administration in hypertensive patients was unclear.
Does hydrochlorothiazide administration correlate changes in RAAS activity with plasma glucose levels in patients with hypertension?
Observational (n=108)
Does hydrochlorothiazide administration correlate changes in RAAS activity with plasma glucose levels in patients with hypertension?
In hypertensive patients treated with long-term hydrochlorothiazide, changes in RAAS activity are correlated with changes in plasma glucose levels, providing insight into thiazide-associated metabolic effects.
Answers are grounded in this paper and cite their sources.
May warrant renin monitoring in thiazide-treated hypertension; leaves open whether RAAS modulation alters glucose responses.
OBJECTIVE: To observe the relationship between changes in renin-angiotensin-aldosterone system (RAAS) activity and blood plasma glucose after administration of hydrochlorothiazide (HCTZ) for one year in patients with hypertension. METHODS: 108 hypertensive patients were given 12.5 mg HCTZ per day for one year. RAAS activity, plasma glucose levels, and other biochemical parameters, as well as plasma oxidized low density lipoprotein (oxLDL) levels, were measured and analyzed at baseline, six weeks, and one year after treatment. RESULTS: After one year of treatment, the reduction in plasma glucose observed between the elevated plasma renin activity (PRA) group (-0.26 ± 0.26 mmol/L) and the nonelevated PRA group (-1.36 ± 0.23 mmol/L) was statistically significant (P < 0.05). The decrease of plasma glucose in the elevated Ang II group (-0.17 ± 0.18 mmol/L) compared to the nonelevated Ang II group (-1.07 ± 0.21 mmol/L) was statistically significant (P < 0.05). The proportion of patients with elevated plasma glucose in the elevated Ang II group (40.5%) was significantly higher than those in the nonelevated Ang II group (16.3%) (P < 0.05). The relative oxLDL level was not affected by the treatment. CONCLUSIONS: Changes in RAAS activity were correlated with changes in plasma glucose levels after one year of HCTZ therapy.
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Xiao et al. (2013) conducted an observational in Hypertension (n=108). Elevated plasma renin activity (PRA) vs. Nonelevated PRA was evaluated on Reduction in plasma glucose (p=<0.05). In hypertensive patients treated with hydrochlorothiazide for one year, elevated plasma renin activity was associated with a significantly smaller reduction in plasma glucose (-0.26 vs -1.36 mmol/L; P<0.05).
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