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July 22, 2003Journal of Hypertension

Metabolic outcome during 1 year in newly detected hypertensives

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Why the study?

Does candesartan (with or without felodipine) improve metabolic outcomes compared to hydrochlorothiazide (with or without atenolol) in newly diagnosed patients with primary hypertension?

Population

392 newly diagnosed patients with primary hypertension, mean age 55 years, 48% men, 94% never treated with…

Comparison

Candesartan, alone or in combination with… vs Hydrochlorothiazide, alone or in combination…

Design

RCT, randomized, double-blind

Follow-up

1 year

Authors

LLLars LindholmPreventive CardiologyMPMats PerssonMedical Products AgencyPAPetar AlaupovicGeneral / Preventive / Lipids

Discussion

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Implication

Supports preferring candesartan-based therapy to reduce new diabetes risk in hypertension; confirms ARBs' metabolic advantage over thiazides in RCTs.

Structured PICO

Does candesartan (with or without felodipine) improve metabolic outcomes compared to hydrochlorothiazide (with or without atenolol) in newly diagnosed patients with primary hypertension?

P
Population
392 newly diagnosed patients with primary hypertension, mean age 55 years, 48% men, 94% never treated with antihypertensive drugs before, from North of Sweden.
I
Intervention
Candesartan (angiotensin-II-receptor blocker), alone or in combination with felodipine (calcium antagonist), for 1 year.
C
Comparator
Hydrochlorothiazide (low-dose diuretic), alone or in combination with atenolol (beta-adrenoceptor blocker), for 1 year.
O
Outcome
Effects on glucose metabolism, lipoprotein metabolism, electrolytes, blood pressure, and subjective symptoms at 1 year.surrogate

Antihypertensive treatment with candesartan (with or without felodipine) has a more favorable metabolic profile compared to hydrochlorothiazide (with or without atenolol) in newly diagnosed hypertensive patients.

Cite This Study

Lindholm et al. (2003) studied this question.

synapsesocial.com/papers/6a7071cfac440176ef291c00https://doi.org/10.1097/00004872-200308000-00022
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antihypertensive Treatment with Candesartan Cilexetil does not Affect Glucose Homeostasis or Serum Lipid Profile in Patients with Mild Hypertension and Type II Diabetes1998 · 23 citations
  2. 2Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge1972 · 32,638 citations
  3. 3Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)2002 · 5,708 citations