Why the study?
Does candesartan cilexetil improve blood pressure, insulin sensitivity, and sympathetic drive compared to hydrochlorothiazide in obese hypertensive individuals?
Population
127 obese hypertensive individuals, mean age 50.7 +/- 5.1 years
Comparison
Candesartan cilexetil 8-16 mg oral once daily… vs Hydrochlorothiazide 25-50 mg oral once daily for…
Design
RCT, randomized, two-parallel-groups, double-blind, placebo-controlled
Follow-up
12 weeks
Authors
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Supports candesartan preference over HCTZ in obese hypertension; extends ARB evidence to metabolic and sympathetic benefits.
Does candesartan cilexetil improve blood pressure, insulin sensitivity, and sympathetic drive compared to hydrochlorothiazide in obese hypertensive individuals?
In obese hypertensive patients, candesartan provides similar blood pressure reduction to hydrochlorothiazide but offers additional benefits by improving insulin sensitivity and reducing sympathetic nerve activity.
Grassı et al. (2003) studied this question.
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