Why the study?
Does hydrochlorothiazide alter plasma levels of triglycerides, total cholesterol, and HDL-cholesterol in patients with essential hypertension?
Population
10 patients with essential hypertension
Comparison
Hydrochlorothiazide 50 mg twice daily for 9 months vs Placebo periods of 4 weeks before and after the…
Design
Other
Follow-up
9 months
Authors
Loading...
May warrant lipid monitoring with hydrochlorothiazide; hypothesis-generating observation leaves open CV outcome impact.
Does hydrochlorothiazide alter plasma levels of triglycerides, total cholesterol, and HDL-cholesterol in patients with essential hypertension?
Hydrochlorothiazide treatment for 9 months in patients with essential hypertension significantly increases total cholesterol levels, suggesting a potential adverse metabolic effect.
Brummelen et al. (1979) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: