What does this research mean for the field?

The dose of hydrochlorothiazide required to achieve goal blood pressure varies among hypertensive patients and is determined by either differing volume losses in response to a given dose or differing degrees of blood pressure reduction in response to the same volume loss. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1988HypertensionOpen Access

Volume (weight) loss and blood pressure response following thiazide diuretics.

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Why the study?

Does hydrochlorothiazide dose requirement correlate with weight loss and blood pressure reduction in patients with mild to moderate hypertension?

Population

343 patients with mild to moderate hypertension (diastolic BP 95-114 mm Hg)

Design

Cohort

Follow-up

10 weeks

Authors

EFE. D. FreisBoston Medical Center DRDomenic J. RedaPreventive Cardiology BMBarry J. MatersonPreventive Cardiology

Discussion

Member takes

Implication

Variable hydrochlorothiazide dosing linked to weight loss may optimize BP control; hypothesis-generating for personalized diuretic therapy.

Structured PICO

Does hydrochlorothiazide dose requirement correlate with weight loss and blood pressure reduction in patients with mild to moderate hypertension?

Population

343 patients with mild to moderate hypertension (diastolic BP 95-114 mm Hg)

Intervention

Hydrochlorothiazide alone, titrated from 50 to 100 to 200 mg daily as needed until diastolic BP fell below 90 mm Hg or side effects supervened

Outcome

Correlation between weight change (as an index of volume loss) and blood pressure reduction (attaining goal diastolic BP < 90 mm Hg)surrogate

Diuretic dose requirements for hypertension vary among patients and depend on differing volume losses or differing blood pressure responses to the same volume loss.

Cite This Study

Freis et al. (1988) studied this question.

synapsesocial.com/papers/6a129c75ea48cb855a352d02 https://doi.org/10.1161/01.hyp.12.3.244

Topics

Hypertension management

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September 1, 1988HypertensionOpen Access

Volume (weight) loss and blood pressure response following thiazide diuretics.

View Full Paper

Ask AI

Bookmark

Why the study?

Does hydrochlorothiazide dose requirement correlate with weight loss and blood pressure reduction in patients with mild to moderate hypertension?

Population

343 patients with mild to moderate hypertension (diastolic BP 95-114 mm Hg)

Design

Cohort

Follow-up

10 weeks

Authors

EFE. D. FreisBoston Medical Center DRDomenic J. RedaPreventive Cardiology BMBarry J. MatersonPreventive Cardiology

Discussion

Member takes

Implication

Variable hydrochlorothiazide dosing linked to weight loss may optimize BP control; hypothesis-generating for personalized diuretic therapy.

Structured PICO

Does hydrochlorothiazide dose requirement correlate with weight loss and blood pressure reduction in patients with mild to moderate hypertension?

Population

343 patients with mild to moderate hypertension (diastolic BP 95-114 mm Hg)

Intervention

Hydrochlorothiazide alone, titrated from 50 to 100 to 200 mg daily as needed until diastolic BP fell below 90 mm Hg or side effects supervened

Outcome

Correlation between weight change (as an index of volume loss) and blood pressure reduction (attaining goal diastolic BP < 90 mm Hg)surrogate

Diuretic dose requirements for hypertension vary among patients and depend on differing volume losses or differing blood pressure responses to the same volume loss.

Cite This Study

Freis et al. (1988) studied this question.

synapsesocial.com/papers/6a129c75ea48cb855a352d02 https://doi.org/10.1161/01.hyp.12.3.244

Also Consider

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Topics

Hypertension management

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