Key result
Following a single 25 mg dose of hydrochlorothiazide, natriuretic responses were similar between black and white hypertensive patients, but potassium and aldosterone excretion were notably lower in blacks.
Why the study?
Are there racial differences in the pharmacokinetic, pharmacodynamic, and neurohumoral response to acute dosing with hydrochlorothiazide in hypertensive patients?
Population
18 hypertensive patients (9 black and 9 white, matched)
Comparison
Single dose of hydrochlorothiazide after a… vs Comparison between black and white patient groups
Design
Cohort
Follow-up
36 hours
Authors
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Small matched PK/PD study leaves open mechanisms of racial HCTZ response differences; does not support practice changes in hypertension management.
Are there racial differences in the pharmacokinetic, pharmacodynamic, and neurohumoral response to acute dosing with hydrochlorothiazide in hypertensive patients?
Absolute Event Rate: 265% vs 255%
Racial differences in potassium and aldosterone excretion following acute hydrochlorothiazide administration may explain altered potassium handling in black hypertensive patients.
Ripley et al. (2000) studied Hypertension (n=18). Hydrochlorothiazide (HCTZ) vs. White hypertensive patients (compared to black hypertensive patients) was evaluated on Sodium excretion at 24 hours post-dosing (mEq/24 hours). Following a single 25 mg dose of hydrochlorothiazide, natriuretic responses were similar between black and white hypertensive patients, but potassium and aldosterone excretion were notably lower in blacks.
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