Key result
Subsequent diagnosis of atrial fibrillation after ischaemic stroke (HR 4.05; 95% CI 2.17-7.54) or ischaemic stroke after atrial fibrillation (HR 3.08; 95% CI 1.90-5.00) significantly increased mortality.
Why the study?
Limited evidence is available on the temporal relationship between AF and ischaemic stroke and their impact on mortality in the community.
Population
100 132 individuals across five prospective community cohorts of the BiomarCaRE project
Comparison
AF first vs ischaemic stroke first vs sole diagnosis of either condition
Design
Prospective multicenter community-based cohort study
Follow-up
Median 16.1 years
Authors
Loading...
Bidirectional AF-stroke diagnoses associate with higher mortality; leaves open whether intensified monitoring improves outcomes in observational cohorts.
Cohort (n=100,132)
Yes
Hazard Ratio: 4.05 (95% CI 2.17–7.54)
p-value: p=< 0.001
The temporal relationship between atrial fibrillation and ischaemic stroke is bidirectional, and developing both conditions significantly increases mortality risk regardless of the sequence of onset.
Camen et al. (2019) conducted a cohort in Atrial fibrillation and ischaemic stroke (n=100,132). Subsequent diagnosis of atrial fibrillation after ischaemic stroke vs. No subsequent diagnosis was evaluated on overall mortality (HR 4.05, 95% CI 2.17-7.54, p=< 0.001). Subsequent diagnosis of atrial fibrillation after ischaemic stroke (HR 4.05; 95% CI 2.17-7.54) or ischaemic stroke after atrial fibrillation (HR 3.08; 95% CI 1.90-5.00) significantly increased mortality.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: