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January 1, 2024BMJ Neurology OpenOpen Access

Is there a temporal relationship between atrial fibrillation and stroke? A review

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Key result

Systematic review finds conflicting evidence on the temporal link between AF episodes and stroke.

  • n=11

Why the study?

Continuous cardiac rhythm monitoring enables detection of brief, asymptomatic AF episodes, but whether a temporal relationship exists between AF episodes and stroke remains an open question.

Is there a temporal relationship between atrial fibrillation episodes detected by continuous monitoring and stroke?

Population

11 studies meeting inclusion criteria

Design

Review

Authors

JDJessica D'LimaRKRooj KitisarnHLH. Lim

Discussion

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Overview

Supports cautious use of device-detected AF timing for anticoagulation decisions; leaves open need for rigorous prospective studies.

Study Design

Type

Systematic Review (n=11)

Structured PICO

Is there a temporal relationship between atrial fibrillation episodes detected by continuous monitoring and stroke?

P
Population
11 studies assessing the temporal relationship between atrial fibrillation and stroke
I
Intervention
Continuous cardiac rhythm monitoring for detection of atrial fibrillation episodes
O
Outcome
Temporal association between episodes of atrial fibrillation and ischaemic strokehard clinical

The temporal relationship between atrial fibrillation episodes and stroke remains unclear due to methodological limitations in existing studies, highlighting the need for better-designed research.

Limitations

  • Varying study methodology
  • Lack of control for anticoagulation
  • Inconsistent stroke subtyping
  • Inconsistencies in ischaemic stroke verification
  • Event rate and power issues
  • Lack of controlling for anticoagulation

Cite This Study

D'Lima et al. (2024) conducted a systematic review in Atrial fibrillation and ischaemic stroke (n=11). Continuous cardiac rhythm monitoring for atrial fibrillation episodes was evaluated on Temporal relationship between episodes of atrial fibrillation and stroke. A systematic review of 11 studies found conflicting evidence on the temporal relationship between atrial fibrillation episodes and stroke, with 4 studies showing a strong association and 7 a weak one.

synapsesocial.com/papers/6a0ef7d325c30b2cc7f9fbcehttps://doi.org/10.1136/bmjno-2023-000512
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Temporal Relationship Between Atrial Fibrillation and Ischemic Stroke.2013 · 3 citations
  2. 2Temporal association between atrial fibrillation and ischemic stroke: Systematic review and meta-analysis2024 · 2 citations
  3. 3Temporal relations between atrial fibrillation and ischaemic stroke and their prognostic impact on mortality2019 · 25 citations
  4. 4Ischemic Stroke Temporally Associated With New-Onset Atrial Fibrillation: A Population-Based Registry-Linkage Study2023 · 14 citations
  5. 5Temporal Association Between Episodes of Atrial Fibrillation and Risk of Ischemic Stroke2021 · 104 citations