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March 22, 2021Neurology

Stroke, Timing of Atrial Fibrillation Diagnosis, and Risk of Death

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Why the study?

To evaluate the prognosis and risk of death in patients with ischemic stroke according to the timing of an AF diagnosis.

Does the timing of atrial fibrillation diagnosis affect all-cause mortality in patients with incident ischemic stroke?

Population

1,489 individuals with incident ischemic stroke from the Penn AF Free study

Comparison

Sinus rhythm vs known AF vs AF diagnosed after stroke (≤6 months or >6 months)

Design

Inception cohort study

Follow-up

Median 4.9 years

Authors

ABAnjali BhatlaYBYuliya BorovskiyRKRonit Katz

Discussion

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Member takes

Overview

AF detection soon after stroke signals higher mortality; observational data leaves open whether timing guides targeted interventions.

Structured PICO

Does the timing of atrial fibrillation diagnosis affect all-cause mortality in patients with incident ischemic stroke?

P
Population
1,489 individuals with incident ischemic stroke from the Penn AF Free study
I
Intervention
Atrial fibrillation diagnosed after stroke (AFDAS) ≤6 months or >6 months, or known AF (KAF) before stroke
C
Comparator
Stroke with no atrial fibrillation (sinus rhythm)
O
Outcome
All-cause mortalityhard clinical

Atrial fibrillation diagnosed within 6 months after an ischemic stroke is associated with a significantly higher risk of all-cause mortality compared to stroke patients without AF, independent of comorbidities and antithrombotic use.

Cite This Study

Bhatla et al. (2021) studied this question.

synapsesocial.com/papers/6a7594d0e2440913016002fdhttps://doi.org/10.1212/wnl.0000000000011633
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differences between atrial fibrillation diagnosed before and after stroke: A large real-world cohort study2024 · 9 citations
  2. 2Atrial Fibrillation Known Before or Detected After Stroke Share Similar Risk of Ischemic Stroke Recurrence and Death2019 · 73 citations
  3. 3Is there any difference in mortality rates of atrial fibrillation detected before or after ischemic stroke?2023 · 1 citations
  4. 4Atrial Fibrillation Detected before or after Stroke: Role of Anticoagulation2023 · 21 citations
  5. 5Recurrent vascular events and mortality outcomes in patients with known atrial fibrillation, compared to atrial fibrillation detected early after stroke2024 · 8 citations