September 1, 1991Acta Physiologica Scandinavica

Adenosine modulation of neuroeffector transmission in guinea‐pig uterine smooth muscle

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Population

Guinea-pig uterine smooth muscle preparations

Comparison

Adenosine, N6-[-1-methyl-2-phenylethyl]-adenosine… vs Untreated preparations

Design

Preclinical

Authors

PWPeter WiklundIcahn School of Medicine at Mount Sinai USU. E. SAMUELSONKarolinska University Hospital MHMattias HammarströmKarolinska Institutet

Discussion

Member takes

Implication

Adenosine modulates guinea-pig uterine contractility at reproductive stages; hypothesis-generating and leaves open human translation.

Structured PICO

Population

Guinea-pig uterine smooth muscle preparations (longitudinal and circular muscle layers during different phases of the oestrus cycle)

Intervention

Adenosine (ADO), N6-[(R)-1-methyl-2-phenylethyl]-adenosine (R-PIA), 5'-N-ethylcarboxamideadenosine (NECA), and 8-p-sulphophenyltheophylline (8-PSOT)

Comparator

Untreated preparations

Outcome

Contractile activity (spontaneous, nerve stimulation-induced, and direct muscle stimulation-induced) and transmitter releasesurrogate

Adenosine and its analogues modulate adrenergic neuroeffector transmission in guinea-pig uterine smooth muscle via postjunctional and prejunctional receptors.

Cite This Study

Wiklund et al. (1991) studied this question.

synapsesocial.com/papers/6a20fbf0ca0ee60525c6cc59 https://doi.org/10.1111/j.1748-1716.1991.tb09199.x

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Adenosine modulation of neuroeffector transmission in guinea‐pig uterine smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Adenosine modulation of neuroeffector transmission in guinea‐pig uterine smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider