Key result
Serum intact parathyroid hormone levels were independently associated with brachial-ankle pulse wave velocity (β coefficient 2.1; 95% CI 0.22-3.99; p=0.029) in hemodialysis patients.
Why the study?
To test whether intact parathyroid hormone levels are independently associated with pulse wave velocity, indicating arteriosclerosis progression, in hemodialysis patients.
Are intact parathyroid hormone levels associated with pulse wave velocity in hemodialysis patients?
Cross-Sectional (n=174)
Are intact parathyroid hormone levels associated with pulse wave velocity in hemodialysis patients?
Effect estimate: β coefficient 2.1 (95% CI 0.22-3.99)
p-value: p=0.029
Intact PTH levels are independently associated with increased pulse wave velocity in hemodialysis patients, suggesting a link between PTH and arteriosclerosis progression.
PTH-baPWV association in hemodialysis is hypothesis-generating; prospective studies needed before considering PTH modulation to slow vascular stiffness.
INTRODUCTION: We conducted an observational study to test the hypothesis that intact parathyroid hormone (PTH) levels are independently associated with pulse wave velocity (PWV), indicating arteriosclerosis progression. METHODS: In this cross-sectional study, patients on hemodialysis in whom brachial-ankle PWV (baPWV) was measured from November 2020 to November 2021, were included. RESULTS: One hundred seventy-four patients, with a mean age of 69.9 years (standard deviation [SD], 11.9), were included in this study. In multivariate linear regression analysis, serum intact PTH levels were correlated with baPWV (β coefficient: 95% confidence interval [CI], 2.1 [0.22, 3.99]; p = 0.029). The subgroup analysis, which was divided according to the presence of diabetes, showed that diabetes has a significant interaction between PTH and PWV. CONCLUSION: These results suggest that intact PTH is independently associated with PWV. Moreover, physiological mechanisms characteristic of diabetes may be involved in the association between PTH and arteriosclerosis.
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Kato et al. (2022) conducted a cross-sectional in Hemodialysis (n=174). Intact parathyroid hormone (PTH) levels was evaluated on brachial-ankle pulse wave velocity (baPWV) (β coefficient 2.1, 95% CI 0.22-3.99, p=0.029). Serum intact parathyroid hormone levels were independently associated with brachial-ankle pulse wave velocity (β coefficient 2.1; 95% CI 0.22-3.99; p=0.029) in hemodialysis patients.
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