Key result
Increased arterial stiffness is linked to low triiodothyronine and reduced muscle mass in pre-dialysis CKD.
Why the study?
Cardiovascular disease is the leading cause of CKD mortality, and identifying correctable cardiovascular markers is a priority to personalize medicine.
Do nutritional, hormonal, and inflammatory markers influence brachial-ankle Pulse Wave Velocity (PWV) in pre-dialysis CKD patients?
Cross-Sectional (n=68)
No
Do nutritional, hormonal, and inflammatory markers influence brachial-ankle Pulse Wave Velocity (PWV) in pre-dialysis CKD patients?
Effect estimate: r = -0.24 for triiodothyronine, r = -0.44 for muscle mass
p-value: p=0.04 for triiodothyronine, 0.001 for muscle mass
In pre-dialysis CKD patients, reduced triiodothyronine and markers of protein malnutrition correlate with increased arterial stiffness, suggesting potential modifiable risk factors for cardiovascular disease.
Potential modifiable markers of arterial stiffness in pre-dialysis CKD; hypothesis-generating and requires prospective confirmation before clinical adoption.
Cardiovascular diseases (CVD) are the first cause of chronic kidney disease (CKD) mortality. For personalized improved medicine, detecting correctable markers of CVD can be considered a priority. The aim of this study was the evaluation of the impact of nutritional, hormonal and inflammatory markers on brachial-ankle Pulse Wave Velocity (PWV) in pre-dialysis CKD patients. A cross-sectional observational study was conducted on 68 pre-dialysis CKD patients (median age of 69 years, 41.2% with diabetes mellitus, 52.9% male). Laboratory data were collected, including levels of prolactin, triiodothyronine, TGF α, IL-6, and IL-1β. The high values of brachial-ankle PWV were associated with reduced muscle mass (p = 0.001, r = −0.44), low levels of total cholesterol (p = 0.04, r = −0.26), triglycerides (p = 0.03, r = −0.31), triiodothyronine (p = 0.04, r = −0.24), and prolactin (p = 0.02, r = −0.27). High PWV was associated with advanced age (p < 0.001, r = 0.19). In the multivariate analysis, reduced muscle mass (p = 0.018), low levels of triiodothyronine (p = 0.002), and triglycerides (p = 0.049) were significant predictors of PWV, but age (p < 0.001) remained an important factor. In conclusion, reduced triiodothyronine together with markers of malnutrition and age were associated with PWV in pre-dialysis CKD patients.
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Rusu et al. (2023) conducted a cross-sectional in Pre-dialysis Chronic Kidney Disease (CKD) (n=68). Low triiodothyronine and reduced muscle mass was evaluated on Brachial-ankle Pulse Wave Velocity (PWV) (r = -0.24 for triiodothyronine, r = -0.44 for muscle mass, p=0.04 for triiodothyronine, 0.001 for muscle mass). In pre-dialysis CKD patients, increased brachial-ankle pulse wave velocity (arterial stiffness) was significantly associated with low levels of triiodothyronine, reduced muscle mass, and advanced age.
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