Key result
Cumulative anthracycline doses of 300 mg/m2 significantly altered right ventricular myocardial performance indices, and doses of 200 mg/m2 elevated serum GDF-15 levels compared to pretreatment.
Why the study?
Do GDF-15 levels and tissue Doppler imaging detect early anthracycline-induced cardiomyopathy in children undergoing cancer therapy?
Cohort (n=20)
Do GDF-15 levels and tissue Doppler imaging detect early anthracycline-induced cardiomyopathy in children undergoing cancer therapy?
GDF-15 levels and tissue Doppler imaging may serve as useful surrogate markers for the early detection of anthracycline-induced cardiomyopathy in pediatric cancer patients.
No takes yet. Share an insight, caveat, or question.
GDF-15 and RV indices may flag early anthracycline effects in children; hypothesis-generating and requires prospective validation before practice change.
Kaya et al. (2016) conducted a cohort in Childhood cancer (n=20). Anthracycline therapy vs. Pretreatment levels or ≥6 months post-treatment was evaluated on Right ventricular myocardial performance indices and serum GDF-15 levels. Cumulative anthracycline doses of 300 mg/m2 significantly altered right ventricular myocardial performance indices, and doses of 200 mg/m2 elevated serum GDF-15 levels compared to pretreatment.
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