Key result
High-dose anthracycline exposure in pediatric cancer patients was associated with significantly reduced peak systolic strain and altered diastolic myocardial velocities compared to controls (P<0.05).
Why the study?
Does tissue Doppler and myocardial deformation imaging detect subtle myocardial dysfunction in pediatric cancer patients treated with high-dose anthracyclines compared to healthy controls?
Case-Control (n=36)
Does tissue Doppler and myocardial deformation imaging detect subtle myocardial dysfunction in pediatric cancer patients treated with high-dose anthracyclines compared to healthy controls?
p-value: p=<0.05
Tissue Doppler and myocardial deformation imaging can detect subtle early changes in cardiac function in pediatric cancer patients treated with high-dose anthracyclines before global functional impairment (EF/FS decline) occurs.
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May support strain imaging for early detection before EF decline in children; leaves open outcome prediction and intervention trials.
Yağcı‐Küpeli et al. (2012) conducted a case-control in Pediatric cancer (n=36). High dose anthracyclines vs. Healthy participants was evaluated on Myocardial function parameters including ejection fraction, fractional shortening, isovolumic relaxation time, and strain/strain rates (p=<0.05). High-dose anthracycline exposure in pediatric cancer patients was associated with significantly reduced peak systolic strain and altered diastolic myocardial velocities compared to controls (P<0.05).
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