Key result
In 20 children with cancer, anthracycline treatment (mean cumulative dose 189 mg/m2) was associated with impaired right and left ventricular myocardial performance index.
Why the study?
Does tissue Doppler imaging detect early cardiac dysfunction in children treated with anthracyclines?
Population
20 children (12 males, 8 females) with cancer admitted for a treatment protocol including doxorubicin.
Comparison
Anthracycline treatment vs Pre-treatment baseline (within-subject comparison)
Design
Cohort
Follow-up
at least 6 months after the last treatment
Authors
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May support early tissue Doppler monitoring in pediatric anthracycline recipients; leaves open need for outcome validation before practice change.
Observational (n=20)
Does tissue Doppler imaging detect early cardiac dysfunction in children treated with anthracyclines?
Tissue Doppler imaging can detect subclinical impairment in myocardial performance index in children treated with anthracyclines before conventional systolic and diastolic parameters become abnormal.
Baysal et al. (2010) conducted an observational in Childhood cancers (n=20). Anthracyclines (doxorubicin) vs. Pre-treatment baseline was evaluated on Right and left ventricular myocardial performance index. In 20 children with cancer, anthracycline treatment (mean cumulative dose 189 mg/m2) was associated with impaired right and left ventricular myocardial performance index.
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