Why the study?
Do single doses of isosorbide mononitrate, eprosartan, or captopril improve pulse wave reflection and blood pressure in elderly patients with resistant systolic hypertension?
Population
16 elderly patients with systolic hypertension resistant to conventional antihypertensive therapy, with high…
Comparison
Single doses of isosorbide mononitrate… vs Matching placebo.
Design
RCT, randomized crossover, double-blind
Follow-up
single dose
Authors
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Isosorbide mononitrate may reduce wave reflection beyond BP lowering in elderly resistant hypertension; extends differential effects of antihypertensives on arterial properties.
Do single doses of isosorbide mononitrate, eprosartan, or captopril improve pulse wave reflection and blood pressure in elderly patients with resistant systolic hypertension?
Isosorbide mononitrate, unlike angiotensin II inhibitors, significantly reduces magnified wave reflection in elderly patients with resistant systolic hypertension.
Stokes et al. (2003) studied this question.
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