Key result
Classical Mendelian genetics, candidate gene screening, and genome-wide association studies have not yet defined the majority of the heritability of atrial fibrillation.
A more comprehensive understanding of the genetic underpinnings of atrial fibrillation is required to identify novel molecular pathways and improve risk prediction.
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AF genetic risk prediction remains incomplete; leaves open advanced genomic approaches to uncover pathways and refine stratification.
Tucker et al. (2014) conducted a review in Atrial fibrillation. Classical Mendelian genetics, candidate gene screening, and genome-wide association studies have not yet defined the majority of the heritability of atrial fibrillation.
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