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January 20, 2025Frontiers in Bioengineering and BiotechnologyOpen Access

Placement of an elastic, biohybrid patch in a model of right heart failure with pulmonary artery banding

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Key result

Biohybrid RV patch improves LVEF by ~14% and TAPSE vs sham in rat heart failure.

  • P<0.001
  • n=21

Why the study?

In right heart failure secondary to pulmonary artery banding, an elastic, biodegradable epicardial patch with integrated extracellular matrix digest was evaluated for its potential to inhibit disease progression.

Does epicardial placement of an elastic, biohybrid patch improve cardiac function and reduce remodeling in a rat model of right heart failure with pulmonary artery banding?

Population

Adult male syngeneic Lewis rats aged 6-7 weeks old after pulmonary artery banding

Comparison

Epicardial biohybrid cardiac patch (n = 7) vs sham (n = 10)

Design

Animal experimental study

Follow-up

9 weeks after PAB

Authors

YHYasunari HayashiNagoya UniversitySKSeungil KimUniversity of PittsburghTFTaro FujiiNagoya University

Discussion

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Implication

Hypothesis-generating in rat right heart failure; leaves open translation of biohybrid patch benefits to larger models or clinical use.

Structured PICO

Does epicardial placement of an elastic, biohybrid patch improve cardiac function and reduce remodeling in a rat model of right heart failure with pulmonary artery banding?

P
Population
21 adult male Lewis rats aged 6-7 weeks with right heart failure induced by pulmonary artery banding, followed for 9 weeks.
I
Intervention
Epicardial placement of an elastic, biodegradable biohybrid patch (poly(ester carbonate urethane) urea (PECUU) and porcine cardiac extracellular matrix digest) on the right ventricle 3 weeks after PAB.
C
Comparator
Sham procedure 3 weeks post-PAB (chest opened but no patch placed).
O
Outcome
Cardiac function evaluated using echocardiography and catheterization 9 weeks after PAB (6 weeks after patch application).surrogate

Main Result

Absolute Event Rate: 49.9% vs 35.9%

p-value: p=<0.001

In a rat model of right heart failure with fixed afterload, epicardial application of an elastic biohybrid patch improved biventricular function, moderated pressure stress, and reduced right ventricular fibrosis.

Limitations

  • Translation of findings to larger animals, different intervention time points, or clinical scenarios is uncertain
  • Only one type of patch intervention was studied
  • Macrophage phenotypes were not pursued
  • Did not evaluate the effect of individual patch parameters such as ECM content, mechanical properties, and degradation rate
  • Did not assess cardiomyocyte viability and apoptosis
  • Durability of the observed effects after the patch has fully degraded is unknown

Cite This Study

Hayashi et al. (2025) studied Right heart failure secondary to pulmonary artery banding (n=21). Elastic, biohybrid patch (PECUU-cardiac ECM hydrogel) vs. Sham procedure was evaluated on Left ventricular ejection fraction (p=<0.001). Placement of a degradable, biohybrid patch onto the right ventricle in a rat model of right heart failure improved left ventricular ejection fraction and tricuspid annular plane systolic excursion compared to sham surgery.

synapsesocial.com/papers/6a210ca66bd086c0991e377dhttps://doi.org/10.3389/fbioe.2024.1485740
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Also Consider

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  1. 1Fibroblasts and the extracellular matrix in right ventricular disease2017 · 94 citations
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