Key result
Implantation of a hydrogel-PET composite pericardial patch in canines for up to 12 months resulted in 0 adhesions between the patch and the native pericardium or epicardium.
Why the study?
Does a pHEMA hydrogel-PET composite pericardial patch prevent adhesion formation in a canine model?
Population
Canines (preclinical model)
Design
Preclinical
Follow-up
6, 9, and 12 months
Authors
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Supports preclinical development of anti-adhesion patches; leaves open translation to human cardiac surgery.
Does a pHEMA hydrogel-PET composite pericardial patch prevent adhesion formation in a canine model?
A novel hydrogel-PET composite pericardial patch prevented adhesion formation in canines up to 12 months without significant loss of mechanical strength, though some calcification was noted.
Walker et al. (1992) studied Adhesion formation after cardiac surgery. Hydrogel-PET composite pericardial patch was evaluated on Adhesion formation and epicardial reaction. Implantation of a hydrogel-PET composite pericardial patch in canines for up to 12 months resulted in 0 adhesions between the patch and the native pericardium or epicardium.
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