Key result
Novel coupling index AVI/LVGLS outperforms traditional VVI in detecting age-related cardiovascular function differences.
Why the study?
The clinical value of a novel ventricular-vascular coupling index system in relation to age, gender, and BMI needed exploration.
Does a novel index system of ventricular-vascular coupling (AVI, LVGLS, and AVI/LVGLS) improve the detection of age-related differences in cardiovascular function compared to traditional echocardiographic indexes in healthy volunteers?
Cross-Sectional (n=239)
No
Does a novel index system of ventricular-vascular coupling (AVI, LVGLS, and AVI/LVGLS) improve the detection of age-related differences in cardiovascular function compared to traditional echocardiographic indexes in healthy volunteers?
Absolute Event Rate: 0.709% vs 0.519%
p-value: p=<0.05
A novel ventricular-vascular coupling index system utilizing AVI and LVGLS is more sensitive than traditional echocardiographic indexes in detecting age-related changes in cardiovascular function.
Background: To explore the value of a novel ventricular-vascular coupling index (VVI) system in relation to age, gender and body mass index (BMI). Methods: A total of 239 volunteers with single-center and cross-sectional health screening were enrolled in the study. Subjects were divided according to age (young [18–44 years], middle-age [45–59 years], old [60–80 years]), gender (male, female), and BMI (overweight/obese [BMI ≥24], control [BMI <24]). The left ventricle end-diastolic volume (LVEDV) and left ventricle end-systolic volume (LVESV) provided the left ventricular structure index, while the TDI e′ provided the functional index. Also derived from routine echocardiography were the effective arterial elastance (Ea), left ventricular end-systolic elastance (Ees), and VVI. The novel VVI systems were arterial velocity pulse index (AVI), left ventricular global longitudinal strain (LVGLS), and the AVI to LVGLS ratio (AVI/LVGLS). Results: (1) Middle-age and elderly subjects had higher Ea and lower LVGLS compared to young subjects. AVI and AVI/LVGLS increased progressively from young to middle-age to old subjects. (2) Females had higher Ea, Ees and LVGLS than male subjects. No significant differences in AVI and AVI/LVGLS were observed between males and females. (3) No significant differences in Ea, Ees, VVI, AVI, LVGLS and AVI/LVGLS were observed between the overweight/obese and control groups. (4) AVI/LVGLS was negatively correlated with LVEDV and LVESV and with TDI e′. LVEDV, LVESV and TDI e′ were independent predictors of AVI/LVGLS. (5) The diagnostic performance of AVI/LVGLS was higher than that of VVI in the young and middle-age groups. The diagnostic efficacy of AVI/LVGLS was higher than that of VVI in the young and old groups, and the diagnostic efficacy of AVI was higher than that of Ea. The difference in diagnostic efficacy between LVGLS and Ees was not statistically significant. The differences in diagnostic efficacy between AVI/LVGLS and VVI, AVI and Ea, and LVGLS and Ees were not statistically significant in the middle-age and old groups. Conclusions: The novel index system of ventricular-vascular coupling described here (AVI, LVGLS, and AVI/LVGLS) was more effective than traditional indexes in detecting differences in cardiovascular function between different ages groups. Clinical Trial Registration: The study protocol was registered on the official website of China Clinical Trial Registration Center (ChiCTR2000035937).
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Wu et al. (2023) conducted a cross-sectional in Healthy volunteers (n=239). Novel ventricular-vascular coupling index (AVI/LVGLS) vs. Traditional ventricular-vascular coupling index (VVI) was evaluated on Diagnostic performance (AUC) for differentiating cardiovascular function between young and middle-age subjects (p=<0.05). The novel ventricular-vascular coupling index AVI/LVGLS demonstrated superior diagnostic performance (AUC 0.709) compared to traditional VVI (AUC 0.519) in detecting cardiovascular function differences between young and middle-aged subjects.
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