Why the study?
Does UK 69,578 increase diuresis and natriuresis in patients with stable (NYHA Class 2) chronic heart failure?
Population
6 patients with stable (NYHA Class 2) chronic heart failure
Comparison
UK 69,578 administered as an intravenous… vs Placebo
Design
RCT
Follow-up
4 to 6 hours
Authors
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Supports NEP inhibition for natriuresis in mild HF; extends ANF augmentation to hemodynamic effects in stable patients.
Does UK 69,578 increase diuresis and natriuresis in patients with stable (NYHA Class 2) chronic heart failure?
Inhibition of endopeptidase 24:11 by UK 69,578 in patients with mild heart failure significantly elevates plasma ANF, leading to diuresis, natriuresis, and venodilatation.
Northridge et al. (1990) studied this question.
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