Why the study?
Does the atriopeptidase inhibitor UK 79300 improve left ventricular hydraulic load in patients with congestive heart failure NYHA II and III?
Population
14 patients with congestive heart failure NYHA II and III
Comparison
UK 79300 200 mg or 400 mg single oral dose vs Placebo
Design
Other
Follow-up
90 min
Authors
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Acute atriopeptidase inhibition does not improve LV load in HF; leaves open whether sustained ANP elevation confers benefit.
Does the atriopeptidase inhibitor UK 79300 improve left ventricular hydraulic load in patients with congestive heart failure NYHA II and III?
Acute atriopeptidase inhibition with UK 79300 increases ANP levels but does not significantly alter left ventricular hydraulic load in heart failure patients.
Kromer et al. (1991) studied this question.
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