Key result
In a swine model of chronic hibernating myocardium, glucose uptake was significantly higher in the LAD region compared to the remote region (0.08 vs 0.04 micromol/min/g, P<0.05).
Population
9 swine with instrumentation of the proximal left anterior descending coronary artery with a small, external…
Comparison
LAD constriction vs Remote region of the myocardium
Design
Preclinical
Follow-up
3 months
Authors
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Hypothesis-generating for metabolic shifts in hibernating myocardium; leaves open p38 MAPK targeting in human ischemic heart disease.
Absolute Event Rate: 0.08% vs 0.04%
p-value: p=<0.05
In chronic hibernating swine myocardium, p38 MAPK activation is increased and correlates with enhanced GLUT-4 translocation, suggesting a role in metabolic adaptations.
McFalls et al. (2004) studied chronic hibernating myocardium (n=9). LAD constriction vs. remote myocardial region was evaluated on myocardial glucose uptake by PET imaging under basal, fasted conditions (p=<0.05). In a swine model of chronic hibernating myocardium, glucose uptake was significantly higher in the LAD region compared to the remote region (0.08 vs 0.04 micromol/min/g, P<0.05).
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