Population
Rats with large experimental myocardial infarction and human failing hearts explanted at the time of heart…
Comparison
Trandolapril (ACE inhibitor) treatment in rats vs Sham-operated rats, placebo-treated rats with…
Design
Preclinical
Follow-up
10 weeks (for rats)
Authors
Loading...
May implicate NF-κB/AP-1 in post-MI remodeling; hypothesis-generating in rats, needs human validation.
NF-kappaB and AP-1 are chronically activated in cardiac myocytes in both experimental and human heart failure, suggesting their involvement in the cardiac remodeling process.
Stefan Frantz (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: