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This analysis examines the burden of acute lymphoblastic leukemia (ALL) in children and adolescents in low- and middle-income countries (LMICs) over the past three decades.

June 4, 2026PLoS ONEOpen Access

Burden of acute lymphoblastic leukemia in children and adolescents in low- and middle-income countries from 1990 to 2023 and projections to 2050: A systematic analysis from the global burden of disease study 2023

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This analysis examines the burden of acute lymphoblastic leukemia (ALL) in children and adolescents in low- and middle-income countries (LMICs) over the past three decades.
Analyzed ALL incidence, mortality, and DALYs using GBD 2023 data for children and adolescents (0–19 years) in LMICs.
Applied Joinpoint regression to assess temporal trends and projected burdens to 2050 with the Bayesian Age-Period-Cohort (BAPC) model.
Evaluated attributable risk factors for occupational benzene and formaldehyde exposure.
2023 reported 64,477 new ALL cases and 30,909 deaths in LMICs, with a higher burden in males.
While the overall age-standardized incidence rate (ASIR) declined, absolute cases increased due to population growth.
Projected burden of ALL will decline through 2050, especially in low-income countries, with negligible contribution from occupational benzene and formaldehyde exposure (PAFs < 1%).

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Implication

Systematic analysis evaluates ALL incidence, mortality, and trends in LMICs, indicating a need for improved healthcare access.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a211743d499ed480b170209 https://doi.org/10.1371/journal.pone.0350223

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Burden of acute lymphoblastic leukemia in children and adolescents in low- and middle-income countries from 1990 to 2023 and projections to 2050: A systematic analysis from the global burden of disease study 2023

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Discussion

Implication

Cite This Study

Burden of acute lymphoblastic leukemia in children and adolescents in low- and middle-income countries from 1990 to 2023 and projections to 2050: A systematic analysis from the global burden of disease study 2023

Key Points

Discussion

Implication

Cite This Study

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