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June 2, 2026Open Access

Development and Validation of Simultaneous Equation Method for Estimation of Empagliflozin and Sitagliptin Phosphate Monohydrate in Bulk and Dosage Form by Uv Spectroscopy

Malathi S Sujithshankar NK

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Key Points

To develop and validate a UV spectrophotometric method for estimating empagliflozin and sitagliptin in bulk and dosage forms.
Created a UV spectrophotometric method using a 70:30 water and methanol mix.
Measured absorbance at 224 nm for empagliflozin and 267 nm for sitagliptin.
Tested method accuracy across concentration ranges with ICH guidelines for linearity and precision.
Achieved a correlation coefficient of 0.99579 for empagliflozin and 0.99295 for sitagliptin.
Maintained %RSD of less than 2% across all parameters, demonstrating high precision.
Method is suitable for quality control of mixed dose forms containing empagliflozin and sitagliptin.

Implication

Develops a UV method to estimate drug concentrations in bulk and dosage forms, suggesting a reliable quality control approach.

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Cite This Study

Malathi S Sujithshankar NK (2026) studied this question.

synapsesocial.com/papers/6a2117dfd499ed480b170b89 https://doi.org/10.5281/zenodo.20508076

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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