Key result
A UV Spectrophotometric method for determining empagliflozin content demonstrated good linearity (R2=0.998) and a minimum sum of square error of 0.0595 in the range of 1.0–3.0 μg/mL.
Effect estimate: R2=0.998
A rapid and specific UV spectrophotometric method was successfully developed and validated for the routine analysis of empagliflozin in bulk and commercial formulations.
Supports lab empagliflozin assays; leaves open clinical adoption pending further validation.
A rapid, specific and economic UV Spectrophotometric method has been developed using a solvent composed of water: methanol (9.0:1.0) to determine the empagliflozin content in bulk. At a pre-determined λmax of 224 nm, it was proved linear in the range of 1.0–3.0 μg/mL, and exhibited good correlation coefficient (R2=0.998) and minimum sum of square error 0.0595, Hence we have selected equation of line of 50–90% (best fit line) linearity throughout experiment. The method was validated statistically and by recovery studies for linearity, precision, repeatability, and reproducibility. The obtained results proved that the method can be employed for the routine analysis of empagliflozin in bulks as well as in the commercial formulations.
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Patil et al. (2017) studied this question. UV-Spectrophotometric method was evaluated on Linearity for empagliflozin determination (R2=0.998). A UV Spectrophotometric method for determining empagliflozin content demonstrated good linearity (R2=0.998) and a minimum sum of square error of 0.0595 in the range of 1.0–3.0 μg/mL.
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