Key result
Diabetes generally downregulates cardiac beta1- and beta2-adrenoceptors and upregulates beta3-adrenoceptors in preclinical models, though downstream signaling and functional outcomes remain highly conflicting.
Why the study?
Changes in β-AR responsiveness contribute to diabetic cardiac dysfunction, but prior studies report inconsistent molecular and functional findings.
This review highlights the complex and inconsistent alterations of cardiac beta-adrenoceptors in diabetes, emphasizing the urgent need for standardized, human-focused research.
Preclinical inconsistencies do not support changes to beta-blocker therapy in diabetes; leaves open standardized human studies on receptor subtypes.
Diabetes is a chronic, endocrine disorder that effects millions of people worldwide. Cardiovascular complications are the major cause of diabetes-related morbidity and mortality. Cardiac β1- and β2-adrenoceptor (AR) stimulation mediates positive inotropy and chronotropy, whereas β3-AR mediates negative inotropic effect. Changes in β-AR responsiveness are thought to be an important factor that contributes to the diabetic cardiac dysfunction. Diabetes related changes in β-AR expression, signaling, and β-AR mediated cardiac function have been studied by several investigators for many years. In the present review, we have screened PubMed database to obtain relevant articles on this topic. Our search has ended up with wide range of different findings about the effect of diabetes on β-AR mediated changes both in molecular and functional level. Considering these inconsistent findings, the effect of diabetes on cardiac β-AR still remains to be clarified.
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Erdoğan et al. (2020) conducted a review in Diabetic cardiac dysfunction. Diabetes mellitus vs. Non-diabetic state was evaluated on Changes in beta-adrenoceptor expression, signaling, and function. Diabetes generally downregulates cardiac beta1- and beta2-adrenoceptors and upregulates beta3-adrenoceptors in preclinical models, though downstream signaling and functional outcomes remain highly conflicting.
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