Why the study?
Does pretreatment hyponatremia predict increased mortality in patients with severe chronic heart failure?
Population
161 consecutive patients with severe chronic heart failure in NYHA class III-IV, mean age 67 +/- 10, 113…
Comparison
Pretreatment hyponatremia (Na+ < 135 mmol/L) vs No hyponatremia (Na+ >= 135 mmol/L)
Design
Cohort
Follow-up
up to 60 months (mortality reported at 24 months)
Authors
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May inform prognosis in severe chronic HF; leaves open whether correction alters outcomes.
Does pretreatment hyponatremia predict increased mortality in patients with severe chronic heart failure?
Pretreatment hyponatremia is a strong predictor of cardiovascular mortality in patients with severe chronic heart failure, with severe hyponatremia (<130 mmol/L) associated with 100% mortality within six months.
Panciroli et al. (1990) studied this question.
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